Scientist II - Molecular Biologist

Scientist II, Center for Innovations & Biodesign, BBG

General Summary

Responsible to manage, supervise and coordinate all scientific activities of the Cellular and Molecular Engineering lab for the Center for Innovations and Biodesign at BBG-R&D. The responsibilities include applied research, early new product or service development, clinical trials/translational research, data collection, analysis, and scientific publication.

Commit to and abide by the character of BioBridge Global’s Core Values of Accountability, Stewardship, Pioneer, Integrity, Respect and Excellence (ASPIRE). Support, communicate and reinforce the mission and vision of the enterprise.

Provide world class customer service by capturing and being responsive to the voice of the customer (internal or external, including donors for select positions) through multiple feedback channels in order to resolve issues and drive satisfaction in accordance with the BBG customer engagement, feedback, and complaint processes.

Major Duties and Responsibilities

Essential Tasks

·         Responsible for the performance of research projects, whether performed personally or delegated.

·         Manage, and coordinate all research, early new product and/or service development, and specialty projects, including any clinical-trial support and Investigational New Drug (IND) studies.

·         Assist in managing the BBG-R&D lab.

·         Conduct, supervise assigned regenerative medicine-related research and development, including analytical assays.

·         Train and supervise junior staff and implement all relevant facility policies and procedures.

·         Proficiency in the culture of mammalian cells, primary cells, flow cytometry, and cell-based assays with meticulous record-keeping.

·         Actively contribute to the successful and efficient execution of robust, state-of-the-art multicolor flow cytometry method for the characterization of the CAR T-cell, CAR-NK, and CAR-M manufacturing process.

·         Design and perform in vitro biochemical and cell-based functional assays using primary or engineered cells (e.g. ELISA, flow cytometry, immune cell proliferation/cytotoxicity assay and immunofluorescence imaging, etc.).

·         Isolation of primary human immune cells from whole blood, buffy coat.

·         Process engineering and development for closed-system manufacturing process.

·         Cell therapy upstream process development and analytics, including product T-cell characterization, process parameter optimization, and single-use bioreactors.

·         Evaluation of immune cell and other cell types for their characteristics using flow cytometry-based assays (e.g. surface marker expression, intracellular staining).

·         Design, plan, and independently perform in-vitro experiments, using a variety of molecular biology techniques.

·         Isolation, culturing, and analyzing hematopoietic/lymphoid lineage cells.

·         Data analysis using FlowJo, and GraphPad.

·         Production and characterization of viral vectors and analytical methodology, including ELISA and SDS-PAGE/ Western blot.

·         Develop a closed-system process for new product development initiatives.

·         Regularly report back to supervisor on the progress of work. Summarize and present results to supervisor in a logical manner, verbally and in written reports.

·         Present work at group and departmental meetings; contribute to the drafting of protocols, method development reports, and peer-reviewed publications.

·         Possess the desire and ability to work in a team environment under limited supervision.

·         Contribute to lab and equipment maintenance and order supplies/reagents to help create a safe, effective and efficient working environment.

·         Analyze, interpret, and present data, troubleshoot experiments, and provide an accurate summary to the management.

·         Apply Quality by Design (QbD) methodology and Design of Experiments (DoE) approach in development to maximize capacity and reduce cost of goods.

·         Participate in regional, national, and international scientific forums on behalf of BBG-R&D.

·         Provide guidance to team-oriented work projects for the development and implementation of strategic initiatives- validations, process improvements, and Standard Operating Procedures (SOPs).

·         Demonstrate utilization of performance excellence principles by:Using data and facts to plan and make decisions.Ensuring that organizational goals/strategic objectives are converted to appropriate actions to align work.Measuring and monitoring progress toward achieving the goals/strategic objectives.

·         Always maintain a professional demeanor while representing BBG-R&D.

·         Perform duties of the management under your supervision during their absences.

Performs other duties as assigned.

Non-Essential Tasks

Education

Required Minimum Education

Requires a Master’s Degree from an accredited college or university.

Preferred Education

Licenses and/or Certifications

·         Valid United States Driver’s License

Experience

Required Minimum Experience

·         Requires three or more years of relevant life science experience.

·         Requires experience with cell culture relevant to Mesenchymal Stem Cells (MSCs), induced-Pluripotent Stem Cells (iPSCs), Hematopoietic Stem Cells (HSCs), Neural Stem Cells (NSCs), Cancer Stem Cells, PBMCs, Cord blood, and Exosomes.

·         Requires experience with microfluidic manipulation of cells and DNA using fluid-flow, electric and/or magnetic fields.

·         Requires experience with FlowJo, GraphPad and ImageJRequires expertise in cell isolation technologies.

Preferred Experience

·         Strongly prefer regenerative medicine applied research and product development experience.Prefer cellular therapies-related assay development experience.Prefer a background in cGMP principles and Quality Management Systems as well as experience in a GMP manufacturing and/or Quality Control testing environment.Expertise in closed-system process development is a plus.Hands-on experience with flow cytometry, PCR, and cell-based potency assays is a plus.Hands-on experience with gene editing techniques (transfection, transduction, and lipofection) is a plus.

Experience Exception to Education

Knowledge

·         Requires basic lab skill knowledge (pipetting, dilutions, titrations, calculating doubling time, etc.).

·         Must maintain knowledge of and perform according to Standard Operating Procedures (SOPs) and policies.

Skills

·         Must maintain competency in laboratory skills for liquid and material handling.

·         Must demonstrate the ability to solve technical and/or clinical problems with biotechnology-based solutions.

·         Must have excellent hands-on laboratory skills.

·         Must be capable of operating motor vehicles in all types of weather conditions.

·         Must have excellent written and oral communication skills.

·         Must have excellent interpersonal and public speaking skills.

Abilities

·         Must have the ability to train others to a competent level.

·         Must be able to keep information confidential.

·         Must be neat in appearance and well groomed.

·         Must be a self-starter and self-directed worker.

·         Must be professional, detail oriented, self-motivated, innovative, creative, assertive, organized, communicative, and have the ability to work independently.

·         Must perform well in repetitive work situations.

·         Must be able to work with interruptions, meet deadlines, and perform accurate work and/or reports.

·         Must be able to work independently as well as in a team environment.

Physical Requirements

Must be able to drive on behalf of the organization.

Will sit, stand, walk, and bend during working hours.

Requires manual and finger dexterity and eye-hand coordination.

Requires normal or corrected vision and hearing corrected to a normal range.

Notice of Labor Condition Application Filing

This serves as notice pursuant to 20 C.F.R. § 655.734
that a Labor Condition Application (LCA), Form ETA-9035E, is being filed with the U.S. Department of Labor for the following:

Employer:                                           BioBridge Global

Classification Sought:                         H-1B Nonimmigrant

Number of Workers:                           1

Job Title:                                             Scientist II - Molecular Biologist

Occupational Classification:               19-1029.02, Molecular and Cellular Biologists

Wage Range Offered:                         $62,000 to $98,000 per year for full-time employment

Dates of Intended Employment:          3/30/2027 to 03/29/2030

Work Location:                                  6211 IH 10 West, San Antonio, Texas 78201

The Labor Condition Application is available for public inspection at BioBridge Global’s principal place of business: 6211 IH-10 West, San Antonio, Texas 78201.

Complaints alleging misrepresentation of material facts in the Labor Condition Application and/or failure to comply with the terms of the Labor Condition Application may be filed with any office of the Wage and Hour Division of the United States Department of Labor.