Post-Doctoral Research Fellow

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Campbell Lab (Basic Sciences Division, Fred Hutch) is recruiting a Post-Doctoral Research Fellow for an appointment to provide continuity and complete ongoing projects at the intersection of integrin structural biology, molecular evolution, and protein biochemistry. The fellow will finalize analyses and a manuscript examining how evolution shapes ligand specificity and promiscuity in αL- and αM-integrin I domains by integrating multiplexed mutational scanning, cryo-EM, evolutionary analysis, and biochemical validation. The successful candidate must be able to work independently with established project-specific constructs, datasets, analysis workflows, and collaborators.

Further information on the lab’s research projects can be found at: https://research.fredhutch.org/campbell/en/research.html

Responsibilities

Responsibilities

- Complete and publish studies of integrin αI-domain evolution, ligand recognition, and activation

- Integrate αLβ2 and αMβ2 cryo-EM structures with evolutionary, mutational, and biochemical data

- Finalize analysis of high-throughput mutational-scanning datasets

- Perform phylogenomic and structure-guided evolutionary analyses

- Conduct targeted protein production and biochemical or biophysical experiments

- Prepare manuscripts, figures, data deposits, and revisions

- Mentor junior researchers and participate in lab and collaborative meetings

Other Expectations:

- Work collaboratively within the Campbell Lab, and with Fred Hutch and external collaborators.

- Show respect to all members of the lab and the broader Fred Hutch community.

Qualifications

MINIMUM QUALIFICATIONS:

- A recently completed Ph.D. in a relevant biological discipline

- Expertise in integrin structural biology and molecular evolution

- Experience with αI-domain integrins, receptor-ligand interactions, and activation

- Proficiency in recombinant protein production, biochemistry, cryo-EM, and structure analysis

- Experience analyzing high-throughput protein-variant datasets

- Expertise in phylogenomics, remote-homology detection, and structure-guided evolutionary analysis

- First-author publications in integrin biology and evolutionary protein analysis

- Strong communication, independence, and collaboration skills

PREFERRED QUALIFICATIONS:

- Direct familiarity with the Campbell Lab's ongoing αI-domain integrin projects, associated cryo-EM and mutational-scanning datasets, and existing analysis pipelines

- Experience bridging structural biology, evolutionary genetics, and protein biochemistry in a multi-laboratory collaboration

The annual base salary range for this position is from $80,172 to $95,014, and pay offered will be based on experience and qualifications. This position may be eligible for relocation assistance.Although Fred Hutch is not sponsoring most H-1B visas at this time, candidates who already hold an H-1B sponsored by another organization and are currently in the U.S. may be eligible for this position.Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).

## Additional Information
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at [email protected] or by calling 206-667-4700.