About this role
Responsibilities will include:
- Preparing DNA and RNA sequencing libraries using established and novel chemistries.
- Developing, optimising and troubleshooting molecular biology protocols, including nanopore sequencing workflows.
- Planning and independently delivering research projects from experimental design through to data generation and evaluation within an agile research environment.
- Performing preliminary data analysis and visualisation using appropriate bioinformatics tools.
- Maintaining clear experimental records and producing high-quality protocols, technical reports and project updates.
- Collaborating effectively with multiple teams across Oxford Nanopore.
- Providing technical guidance and mentorship to junior colleagues and interns.
- Staying up to date with developments in sequencing technology, molecular biology and RNA research.
What We’re Looking For...
Essential skills and experience:
- PhD , or equivalent research experience, in RNA biology, molecular biology, biochemistry, chemical biology or a related discipline.
- Proven background in RNA molecular biology, including RNA purification, enzymatic manipulation and integrity assessment.
- Strong understanding of RNA stability, degradation, secondary structure and enzymology.
- Demonstrated ability to independently design, optimise and troubleshoot complex experiments.
- Familiarity or willingness to develop proficiency in Python, Bash or command-line bioinformatics tools.
Desirable skills and experience:
- Experience with long-read transcriptomics, ideally Oxford Nanopore direct-RNA sequencing.
- Experience working with synthetic, chemically modified or therapeutic RNA molecules, including an understanding of RNA modification and end chemistry.
- Experience developing RNA manipulation, capture or library-preparation methods, and/or studying RNA structure or interactions.
- Familiarity with computational tools for bioinformatics analyses and data visualization.
- Knowledge of functional genomics, including nucleotide modifications and genome regulation.