About this role
Position Title: Senior Research Associate, Radiopharmacology
Reporting Location: Rockville, MD (onsite)
Reports To: Head of Radiochemistry and Radiopharmacology
Primary Objective: Performs cross-functional laboratory assays with a focus on radiolabeling and in vitro/in vivo characterization of radiolabeled compounds. Assists in the development and execution of novel assays including collecting, processing and communicating data.
Join our team to advance radiochemistry and cancer research, supporting our growing radioconjugate program. Support the operations and commercial teams in the planning and execution of studies utilizing radioconjugates for testing in Champions extensive PDX TumorBank in in vitro and preclinical mouse pharmacology studies.
DUTIES, RESPONSIBILITIES AND PRODUCTIVITY EXPECTATIONS:
- Perform radiolabeling and purification of radiolabeled compounds using isotopes such as Lu-177, Ac-225, Pb-212, Cu-64, and Zr-89.
- Perform quality control of radiolabeled compounds using radio-TLC and radio-HPLC.
- Perform in vitro assays (e.g., receptor binding, internalization, stability studies) using radiolabeled compounds in cell-based systems.
- Perform dose preparation and sample processing for in vivo radiopharmacology studies.
- Contribute to the development of SOPs and assay workflows for conjugation, radiolabeling, and in vitro characterization of radiolabeled compounds.
- Contribute to data processing and preparation for client presentation.
- Lead small scale projects that are specific to radiopharmacology operations.
- Operate and maintain radiochemistry equipment including dose calibrators, gamma counters, and radio-TLC/HPLC systems.
- Follow radiation safety protocols and institutional regulations, and maintain accurate records in electronic lab notebooks (ELNs).
- Mentor and guide entry level research associates in assay training and technical development.
- Documentation and maintenance of laboratory and supply inventory by working with facilities and procurement team.
- Contribute to the culture of the radiopharmacology group by demonstrating high performance, sporting accountability and fostering collaboration and teamwork.
- Other duties may be assigned verbally at any time.
Qualifications
KNOWLEDGE, SKILLS, AND ABILITIES:
- Proficiency in general chemistry or biochemistry laboratory techniques, including preparing buffers and solutions, weighing chemical substances, and using micropipettes.
- Experience with radiolabeling, radio-TLC/HPLC, or handling radioactive materials is preferred but not required.
- Experience with cell culture and cell-based assays.
- Experience managing small-scale projects and maintaining strong communication skills are required.
- Demonstrated ability to work effectively and productively in a team-oriented environment while maintaining a strong sense of integrity and confidentiality.
- Creative problem-solving skills and the ability to exercise sound and accurate judgment in making timely decisions.
- Strong planning, organizational, computer, written and verbal communication skills.
- Demonstrated accountability, initiative, and responsibility for own work.
- Ability to observe safety and security procedures.
- Ability to assist with other tasks/duties as needed in a small company environment.
EDUCATION AND EXPERIENCE:
- BS or MS degree with 3-5 years of relevant experience required. Preferred field of study in radiochemistry, chemistry, biochemistry, biology, or related sciences.
- Laboratory-based experience performing chemistry or biochemistry reactions is required.
- Previous experience working with radioactive materials is preferred but training will be provided.
PHYSICAL DEMANDS AND WORK ENVIRONMENT:
- Must be able to sit and use hands to finger, handle and feel.
- Must be able to lift and move packages weighing up to 50 pounds.
- Some activities require repetitive motion and reaching, pulling, or pushing.
- In carrying out the duties of the job, there will be frequent exposure to fumes, chemical hazards, and radioactive materials under controlled conditions.
- Duties performed routinely require exposure to blood, body fluid, and tissue.
This description reflects managements assignment of essential functions, it does not proscribe or restrict the tasks that may be assigned. We celebrate diversity and a re committed to creating an inclusive environment for all employees.