Senior Scientist I, Discovery Pharmacology

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead is seeking a senior scientist to join our Biology Research Department. The candidate will be a key member of the Discovery Pharmacology team.

Responsibilities

- Design, execute and interpret in vitro, ex vivo and in vivo studies to facilitate drug discovery and development by way of understanding mechanisms of action

- Develop and optimize new cell-based functional assays to achieve project goals

- Support Biology and cross-functional team members in understanding various aspects of drug mechanism

- Independently read and apply relevant scientific literature to projects, troubleshoot and solve problems

- Present research findings to project teams and governance bodies and prepare technical reports

- Present research findings externally (conferences, journal publications)

- Maintain a high level of productivity in the lab and perform critical experiments

Requirements

- PharmD or PhD degree in immunology, cell biology, molecular toxicology, pharmaceutical sciences or pharmacology.

- 2+ years of pharmaceutical industry or relevant postdoctoral experience.

- Track record of scientific publications in high-profile journals

- Deep understanding of cell biology, immunology, cell-culture and cell-based assay development.

- Experience in drug metabolism and safety

- Demonstrated motivation, tenacity, innovation, creativity and resilience in problem solving

- Excellent oral and written communication skills

- Self-motivated team player with the ability to thrive in a fast-paced, multidisciplinary, matrixed environment

Preferred

- Expertise in immunology and/or molecular toxicology. Experience at the interface of drug metabolism and safety.

Wisconsin pay range $120,000 — $130,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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