Senior Scientist - Non-Clinical Drug Safety

Description

Boehringer Ingelheim is currently seeking a talented and innovative Senior Scientist, Non-Clinical Drug Safety to join our NDS department located at our Ridgefield, CT facility. The primary objective of the Senior Scientist role is to design and execute fit-for-purpose in vitro toxicity studies, with a particular focus on all-in vitro safety packages for T-cell engagers (TcEs) and T-cell receptor mimetics (TCRms). The role is also responsible for proactively developing and applying novel models and technologies to enable tailored, modality-driven safety evaluations of therapeutics throughout discovery, preclinical development, and clinical development. A key responsibility of the role is to provide guidance to project teams and Safety Science Leads regarding in vitro toxicology support.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees.

Duties & Responsibilities

- Independently design, execute, analyze, and interpret in vitro toxicity studies by applying established models, developing new models, or identifying collaboration partners and CROs that offer suitable assays to generate decision-relevant evidence.

- Collaborate closely with Safety Science Leads (SSLs) and other experts in Delivery Teams to develop and execute fit-for-purpose in vitro testing strategies and packages to support our pipeline. Develops an understanding of R&D team goals and works effectively toward achieving them; Either assumes departmental responsibility for projects when necessary or has ability to participate as representative on multiple project teams and contribute to defining expertise-related aspects of overall program goals

- Provide in vitro toxicity support across all modalities including particular focus on T-cell engager (TcE) and T-cell receptor mimetics (TCRm).

- Develops expertise in a specific project-relevant area or technology; apply broad expertise in physiology, cellular systems and assay technologies, to establish and implement innovative in vitro approaches (2D and 3D culture models, micro-physiological systems, and organ-on-chip technologies) addressing emerging project needs.

- May provide guidance and expertise to advance specific projects or evaluate and propose new technologies and concepts in support of multiple projects; Ability to work with various LIMS; Compilation of associated outputs with supervision

- Keeps abreast of relevant literature; Develops visibility outside of functional area

- Complies with all applicable regulations; Ensures that work performed in area of responsibility is conducted in a safe and compliant manner; maintain accurate experimental records, protocols, reports, data packages in accordance with SOPs and policies - provide presentations, and communicate results and strategy clearly to project teams and leadership.

- Manage CRO partnerships end to end, including vendor selection, scopes of work, study oversight, timelines, budgets, data quality, issue resolution, and decision-ready reporting.

- Promote a collegial, inclusive, safe, and solutions-oriented laboratory culture.

Requirements

- Ph.D., D.V.M./V.M.D. Degree or equivalent experience in Cell Biology, Molecular Biology, Immunology, Toxicology or a related discipline

- Post Doctoral experience desirable

- Extensive experience culturing human primary cells (including immune cells), induced pluripotent stem cells (iPSCs), and cell lines with in vitro systems that span across multiple organ systems for translational safety assessments.

- Experience supporting all-in vitro safety packages for TcE, TCRm and/or other NBEs and knowledge about diverse therapeutic modalities.

- Proficiency with cytotoxicity assessments (including plate based, flow cytometry, and/or imaging based read outs) and analysis of soluble biomarkers including cytokines (via MSD or ELISA).

- Proven ability to translate in vitro toxicology findings into actionable insights that support project decisions and pipeline advancement

- Experience leading cross-functional workstreams or external collaborations, including CRO.

- Strong collaboration and communication skills, with a proven ability to influence scientific and portfolio decisions in a matrix organization

- Excellent organizational, analytical, problem-solving, written (including reports for regulatory submissions), oral, and interpersonal communication skills, with a collaborative and approachable working style.

- Strong commitment to laboratory research and active bench engagement.

- Appropriate level of understanding of applicable regulations

Compensation Data

The base salary range for this position is $140,800.00 - $211,200.00 USD. The position may be eligible for a role-specific discretionary bonus, relocation assistance, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, qualifications, and other factors permitted by law. Benefits include medical, dental, and vision coverage, retirement savings opportunities, paid time off, paid holidays, disability and life insurance benefits, and other company-sponsored benefits. For additional information regarding our benefits and Total Rewards offerings, please click here .