Associate Director, Operations- Center for Therapeutic Genectics

The Center for Therapeutic Genetics is a non-profit collaboration among the Broad Institute, Boston Children's Hospital, and The Jackson Laboratory. It develops genetic medicines for rare and ultra-rare diseases and aims to make them a repeatable practice rather than one-off breakthroughs. Roughly 8,000 rare diseases affect an estimated 350–400 million people worldwide, and fewer than one in 20 has an approved treatment.

CTG builds on advances in programmable medicines such as base and prime editing, which can be tailored to an individual patient's mutation. Its platform strategy shares design tools, disease models, manufacturing processes, safety data, and clinical protocols across disease programs. This is meant to make treatment faster, safer, less costly, and more accessible.

Position Summary

CTG is seeking an Associate Director of Operations to build and run the operational, financial, and governance backbone of the center. You will connect strategy to execution across the Broad Institute, JAX-RDTC, and Boston Children's Hospital, and serve as a trusted strategic partner to the CTG Director and senior leadership.

Reporting to the CTG Director and working closely with the broader Broad Institute administration, you will set operational goals and drive them to completion across multiple program teams and institutional partners. You will own the CTG operations budget and the partnership infrastructure, and you will use judgment and data to resolve complex, novel problems that may have no existing playbook. You do not need to be a bench scientist, but you must understand the translational space (nonclinical and clinical) well enough to support CTG's work, and you need the business acumen to advance its mission.

Key Responsibilities

Operational Leadership and Strategy

- Lead the operational framework for CTG, including governance, finance, communications, and logistics. Establish goals and ensure timely execution across the Preclinical, Manufacturing, and Clinical programs and supporting teams.
- Contribute to CTG's strategic direction and priorities with leadership and partners, and translate them into operating plans, timelines, and performance indicators.
- Recommend and implement new policies, processes, and tools as CTG scales. Select the methods and evaluation criteria used to measure results.
- Drive the success of large, cross-cutting initiatives that span multiple teams and institutions.
- Oversee and guide experienced staff and project managers, and where applicable, subordinate managers. Delegate and collaborate across teams to build the capability of direct reports and colleagues.

Financial Management

- Design, manage, and forecast the CTG operations budget, including internal staff and seconded institutional staff, and contribute to building the full CTG budget.
- Take accountability for budget decisions and reporting to fiscal sponsors and partner institutions.
- Work with scientific project managers to track program pipelines, milestones, budgets, and timelines, and flag risks to leadership early.

Governance

- Coordinate logistics, materials, and follow-up for the CTG Oversight Committee, Leadership Teams, , and Scientific Advisory Board. Ensure decisions are documented and cascaded to program teams.
- Partner with the Preclinical, Manufacturing, and Clinical Leads to schedule, resource, and escalate program-level governance gates (e.g., go/no-go reviews) to the Governance Committee.
- Maintain compliance with partner institutions' agreed transactional workflows.

Partnership and Alliance Management

- Act as the primary operational partner to founding partners (JAX-RDTC and BCH) and external collaborators. Maintain and refine tri-institutional governance models and attend key operational and administrative working group meetings.
- Draft and advance memorandums of understanding (MOUs) and related agreements.
- Identify, engage, and onboard new partners and resources.

Communication and Stakeholder Engagement

- Work with senior leaders on matters affecting multiple teams. Influence decisions and build acceptance in sensitive situations without damaging relationships.
- Prepare and deliver executive- and board-level communications on progress, risks, and milestones. Develop and maintain business plans, executive summaries, and presentation decks.
- Capture and synthesize partner meeting discussions and drive action items to completion.
- Support coordination with the Patient & Community Engagement Council and patient advocacy representatives on the Board.
- Serve as the interim point of contact for cross-program data and reporting needs until a Head of Data is hired.
- Work across Broad Administration to advance CTG goals.

Qualifications

Education and experience

- Bachelor's degree with 10+ years of related experience, or Master's with 8+ years, or PhD with 5+ years, in project management, alliance management, strategic consulting, or a related field. Equivalent experience is considered.
- 5+ years of management experience, including leading teams, programs, or cross-functional efforts.
- A background in science, medicine, or a related field is highly preferred, but not required
- Experience with board level communications is highly preferred.

Knowledge and skills

- Advanced understanding of how teams contribute to organizational objectives, and a working understanding of how a large research institution operates.
- Proven record of managing complex projects, timelines, and multi-million-dollar budgets with accountability for results.
- Ability to analyze complex or ambiguous situations, use data to drive decisions, and create practical solutions to unusual problems.
- Intellectual agility to understand and communicate complex scientific ideas to varied audiences.

Core competencies

- Strategic and tactical: balances big-picture thinking with attention to execution detail.
- Interpersonal: high EQ and analytical rigor; builds trust and consensus among diverse stakeholders, including senior leaders.
- Action-oriented: takes initiative, solves problems, and rolls up their sleeves.
- Communication: exceptional written and verbal skills, with a talent for turning complex ideas into clear, actionable materials.

The Broad will not provide sponsorship for this opportunity.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package (https://www.broadinstitute.org/benefits/benefits-working-broad) including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact [email protected] for assistance.