About this role
Position Summary
Korro Bio is seeking a motivated, detail-oriented Research Associate to join our Oligonucleotide Chemistry team. The successful candidate will synthesize, purify, and characterize chemically modified oligonucleotides and conjugates on automated platforms, supplying oligonucleotides for screening across Korro’s discovery programs. This is a hands-on, lab-based role suited to someone with practical oligonucleotide synthesis experience who takes ownership of instrument operation and maintenance, keeps meticulous records, and communicates results clearly to the team and cross-functionally. This position reports to Scientist II and is based on-site in Cambridge, MA.
Key Responsibilities
- Execute solid-phase synthesis, purification, and downstream processing of chemically modified oligonucleotides and oligonucleotides conjugates at different scales using modern automated oligo synthesis platforms
- Operate, maintain & troubleshoot equipment for oligonucleotide synthesis (Mermade 12 and 192), purification, desalting and lyophilization
- Ability to cross-train with other synthesis scales and instrumentation
- Maintain inventory of chemicals and amidites for oligonucleotide synthesis
- Perform in-process and final analytics of oligonucleotide samples as needed
- Track progress, analyze, organize, and present data to team and cross-functionally
- Maintain a well-documented electronic laboratory notebook
- Actively participate in training activities and provide training to others as needed
- Author and review SOPs and technical reports
Required Qualifications
- BS/MS with 1+ years experience in Chemistry, Biochemistry, Biotechnology, or related field
- Hands-on experience in the synthesis, purification, and analysis of oligonucleotides
- Experience with high throughput synthesizers such as Mermade 192 is a plus
- Strong laboratory skills and experience in handling, troubleshooting and routine maintenance of lab equipment including automated synthesis platforms, HPLC and LC-MS etc.
- High degree of flexibility and self-motivation in a fast-paced work environment with excellent organizational skills, ability to prioritize appropriately and meet deadlines.
- Excellent interpersonal, communication and presentation skills.
- Detail-oriented and excellent problem-solving abilities.
Final salary will be determined by the level at which the role is filled and by factors such as skills, competencies, experience, education, and other job-related criteria permitted by law. This range reflects base salary only and does not include annual bonus or equity.