Senior Director, Clinical Translational Scientist

Repertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE TM platform—which maps the immune synapse between T cell receptors (TCRs) and their antigen targets—Repertoire translates unique biological insights into potent and targeted off-the-shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates.

From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company’s lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months. In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system.

Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies—Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer—representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.

Overview:
Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape and advance a portfolio of T cell–targeted therapies in oncology and autoimmune disease. Reporting to the SVP of Integrated Therapeutic Engineering and Development, this individual will play a leading role in development-stage research strategy and execution, driving programs from discovery through IND-enabling studies.

This role requires deep scientific expertise and decisive leadership to define mechanism of action, establish PK/PD and efficacy relationships, and translate novel modalities—including both T cell engager and mRNA/LNP platforms—into clinically actionable programs. The successful candidate will ensure seamless integration across discovery, platform, and development functions.

As a key member of the research team, this individual will influence portfolio direction and execution, accelerating the delivery of differentiated T cell–based therapies to patients.

Responsibilities:
- Lead development and execution of integrated translational medicine strategies across clinical development programs.
- Develop and continually refine biomarker and clinical pharmacology plans to support target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
- Translate emerging biological, pharmacological, and clinical data into actionable development recommendations.
- Identify and prioritize translational milestones to inform key portfolio decisions and stage-gate transitions.
- Define biomarker strategies spanning exploratory, pharmacodynamic, predictive, prognostic, and diagnostic biomarkers.
- Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
- Lead interpretation of biomarker, PK/PD, and clinical datasets to generate insights regarding mechanism of action, treatment response, and resistance pathways.
- Support implementation of innovative technologies and emerging translational approaches.
- Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
- Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
- Contribute translational components to regulatory submissions including INDs, briefing documents, and marketing applications.
- Support interactions with health authorities related to biomarkers, companion diagnostics, and translational strategy.
- Maintain awareness of emerging scientific advances and competitive developments within oncology, immunology, and related therapeutic areas.
- Foster a collaborative, patient-focused, and scientifically rigorous culture.
- Contribute to departmental strategy, capability building, and organizational development.
Qualifications and Experience:
- PhD, MD, or MD/PhD in Immunology, or related discipline.
- Advanced clinical development and translational medicine expertise strongly preferred.
- Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
- Proven ability to integrate scientific, biomarker, and clinical data to deepen the understanding of patient populations and drug mechanism of action in patients.
- Experience leading and influencing cross-functional teams across Research, Clinical Development, and Regulatory Affairs.
- Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies in oncology.
Compensation and Benefits
The base salary for this role ranges from $260,000 to $315,000 and is determined based on a candidate’s skills, experience, and internal equity. In addition to a competitive base salary, Repertoire offers a broad range of benefits designed to attract, retain, and motivate top talent, including medical, dental, vision, and life insurance, flexible time off, a 401(k)-retirement plan, and short- and long-term incentive opportunities. Compensation and benefits are based on Repertoire’s good faith estimate at the time of publication and may be updated in the future.

Repertoire is committed to building an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, we believe our best work comes from a diverse workforce—and we are committed to pursuing that in all facets of the work experience.

Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies:   Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.