2026-066-01 Clean Room – ATMPs Process Development and Quality Technician

The Vall d´Hebron Institute of Oncology (VHIO) Seeks a “ATMPs Process Development and Quality Technician”

Reference: 2026-066-01

Application deadline: until the position is filled

Number of vacancies: 1

Reporting to the ATMP Clean Room’s Qualified Person and working closely with the Quality and Production teams, the mission of the role will be to support the development, optimization and validation of ATMP manufacturing processes, as well as the implementation and operation of the new VHIO GMP clean room.

The successful candidate will participate in activities related to process development, characterization, quality control, GMP documentation and manufacturing operations, supporting the translation of research and preclinical processes into robust and reproducible manufacturing processes suitable for clinical-grade ATMP production.

A major focus of the position will be the development and preclinical evaluation of a single-use bioreactor for the culture and expansion of tumour-infiltrating lymphocytes (TILs), in collaboration with external partners. The project will involve the adaptation and evaluation of the bioreactor for T-cell and TIL expansion, comparison with conventional expansion platforms and characterization of the resulting cellular products.

The position therefore offers the opportunity to work at the interface between cell therapy process development, GMP manufacturing, quality and translational research.

Responsibilities:

- Support the implementation and start-up of the new VHIO GMP clean room, including the preparation and implementation of SOPs, protocols and manufacturing documentation.
- Participate in the development, optimization and validation of ATMP manufacturing processes, including process characterization, scale-up and aseptic process simulations.
- Participate in the development and preclinical evaluation of a single-use bioreactor for TIL expansion, including adaptation of the system, T-cell and TIL expansion, and comparison with conventional systems.
- Perform and support cellular and analytical characterization of TILs and other cellular products, including flow cytometry, viability, phenotype and functional/potency assays.
- Analyse and interpret experimental and process data, prepare technical reports and contribute to the definition of process parameters, quality attributes and acceptance criteria.
- Support quality activities related to process development and manufacturing, including deviations, change controls, risk assessments and CAPAs.
- Ensure appropriate documentation, traceability and data integrity of development and manufacturing activities in accordance with GMP and the VHIO Quality System.
- Collaborate with Production, Quality, Research, Clinical and Regulatory teams, as well as with external companies and research partners involved in technology development and transfer.
- Participate in the preparation of technical and regulatory documentation related to ATMP development and manufacturing.

Requirements:

Education

- Bachelor's or Master's degree in Biotechnology, Biology, Biochemistry, Pharmacy, Chemistry, Biomedical Engineering or a related bioscience discipline.
- Additional training in ATMPs, GMP, cell therapy, bioprocessing or pharmaceutical development will be highly valued.

Experience

- Previous experience in cell culture and cellular biology techniques.
- Experience with human primary cells, preferably immune cells.
- Experience in flow cytometry and cellular characterization.
- Experience in process development, optimization or analytical assay development.

- Experience in T-cell culture and expansion will be highly valued.
- Previous experience with TILs, CAR-T, PBLs or other cell-based ATMPs will be highly valued.
- Experience in a GMP, clean room or other controlled environment will be considered an advantage.

Personal skills

- Strong organizational and planning skills.
- Ability to work independently and as part of a multidisciplinary team.
- Analytical and problem-solving skills.
- Attention to detail and strong commitment to documentation and data integrity.
- Ability to manage multiple activities and priorities.
- Good communication skills and ability to interact with inte

Additional information:

We offer:

- 📈The possibility of developing your professional career in a competitive environment.
- 🧠To be part of a center that is constantly developing, pursuing excellence in research and collaborating with leading teams.
- 🫱🏻‍🫲🏾We offer and promote a diverse and inclusive environment, and welcome all people equally, regardless of age, disability, gender, nationality, race, religion or sexual orientation.
- 🪴We care about our environment and understand the importance of sustainability. We have the GreenVhio program, which you can be a part of.

Conditions:

- 📝Permanent contract. "Este contrato se encuentra financiado por el "Programa Acelerador de Terapias Avanzadas" del "Programa de Excelencia AECC 2022" financiado por la Fundación Científica de la Asociación Española Contra el Cáncer"
- 🗓️Full-time position, 37.5 hours per week.
- 💶Salary according to qualifications and experience following VHIO pay scales.
- 💳Flexible remuneration program (includes restaurant vouchers/cards, transport, medical insurance, and “baby daycare” voucher).
- ⏰Flexible working hours and measures to balance work, family, and personal life, and promote gender equality, as established in the VHIO collective agreement.
- 🗺️24 days of holidays and 6 personal days.
- 🎓Fully subsidized Catalan, Spanish, or English courses.
- 🏃‍➡️Take advantage of doing sports at great prices with WellHub .
- 🩺You’ll have access to weekly physiotherapy sessions at the office, offered at a reduced price for the team.

Vall d’Hebron Institute Oncology (VHIO) endorses the Requirements and Principles of the European Charter for Researchers, the Code of Conduct for the Recruitment of Researchers promoted by the European Commission and follows Equal Opportunities policies.

On 10th April 2018 VHIO was awarded the “HR Excellence in Research” logo. Our Institute was consequently granted permission to use the HR Excellence in Research Award logo as demonstration of its stimulating and favourable work environment in line with the Charter & Code.