Senior Scientist, Cell Pharmacology

Xilio Therapeutics is a development-stage biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines.

Xilio was founded in 2016 and closed a $100.5M Series B financing from blue chip venture investors in February 2020. Xilio is headquartered in Waltham, MA.

SUMMARY:

Xilio Therapeutics is seeking an Associate Scientist to join our In Vivo Pharmacology group. This individual will be responsible for conducting preclinical studies in animal tumor models (efficacy, PK/PD and MOA studies) to characterize immuno-oncology focused protein therapeutics. They will also perform downstream in vitro assays.

RESPONSIBILITIES:

- Design and execute studies to investigate the efficacy, safety and PK/PD of protein therapeutics including analysis of data with the appropriate statistical tools

- Perform routine animal handling procedures and injections (SC, IP, IV, PO, IT) in mice, monitor animal health, measurements, and tissue collection for ex vivo analysis

- Support the implementation and validation of new animal models

- Meet all guidelines set by Xilio’s IACUC

- Perform ex vivo analysis including ELISA, ELISpot, MSD, flow cytometry

- Ensure data is captured in appropriate databases and electronic laboratory notebooks

- Regular participation and presentation at Project Team and departmental meetings.

- Collaborate with other members of the In Vivo Pharmacology team

REQUIREMENTS:

- M.S. or B.S. in the field of immuno-oncology, or other related fields with 3-5+ years (B.S.) or 1-2+ years (M.S.) experience working in a CRO, biotechnology or pharmaceutical company

- Technical experience with development, qualification, and execution of studies in subcutaneous syngeneic tumor models (orthotopic tumor models is a plus), as well as PDX and/or humanized tumor models

- Experience with cell culture of primary cells and cell lines

- Experience with IACUC documentation

- Experience with pharmacokinetic analyses would be preferred

- Experience with ELISA and/or FACS analyses of in vivo models is desirable

- Strong communication and teamwork skills are essential as this individual is expected to operate in a fast-pace multi-disciplinary environment

Xilio offers the opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology. We offer a competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off.

POSITION: Full-Time, Exempt

EEOC Statement: Xilio Therapeutics believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Xilio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.